Article categories:
Describes characteristics of eleven EM patients in one center; proposes a diagnostic algorithm (page 8)
PDFcategory: Treatment
Explains the discovery that a gene variation in potassium channels called Kv7.2 and Kv7.3 can reduce an individual’s sensitivity to pain
PDFcategory: Research
This study suggests that genetic factors, along with environmental/social factors, play a role in pain resilience and could help explain the variability in pain experience among individuals with erythromelalgia.
PDFcategory: Research
It is our strong belief that there is a viable future in the targeting of protein of Nav1.7 for the relief of chronic pain
in humans.
category: Treatment
This article focuses on the discovery of a new gene variant that is associated with EM. The researchers found that the gene variant, located in the NTRK1 gene, can lead to the development of EM in some individuals. The study sheds light on the genetic causes of this debilitating condition and could lead to new treatments for individuals affected by EM.
PDFcategory: Research
Study finds dorsal root ganglion stimulation produces less paresthesia (i.e. pins-and-needles sensation) than spinal cord stimulation when used to treat chronic pain.
PDFcategory: Pain and Other Related Topics
Studies find that a drug used in cough syrup and cold medicines could be used topically to treat neuropathic pain.
PDFcategory: Pain and Other Related Topics
Analysis of existing studies of pediatric chronic pain patients finds that catastrophizing produced a strong relationship with anxiety, depression, and quality of life, as well as a moderate relationship with physical functioning and pain intensity.
PDFcategory: Pain and Other Related Topics
Researchers identify hormones that may benefit chronic pain patients.
PDFcategory: Pain and Other Related Topics
International Association for the Study of Pain develops classification system for subgroups of chronic pain.
PDFcategory: Pain and Other Related Topics
Discussion of the challenges faced by primary care providers in treating chronic pain and the need for more effective self-management strategies.
PDFcategory: Pain and Other Related Topics
Q&A with radiology specialists on using magnetic resonance neurography to diagnose peripheral nerve pain.
PDFcategory: Pain and Other Related Topics
Stem cell technology was used to identify personalized treatment for a patient with small fiber neuropathy.
PDFcategory: Pain and Other Related Topics
Case report of a 56-year-old female with secondary EM triggered by oral cyclosporine.
PDFcategory: General EM
Case report of a 9-year-old girl treated with carbamazepine.
PDFcategory: Treatment
Comprehensive review of literature on treatment approaches for EM.
PDFcategory: Treatment
Comprehensive review of studies on neuropathic pain conditions provides an overview of genetic variants implicated.
PDFcategory: Pain and Other Related Topics
Discussion of EM treatment options, using approach based on drug’s mechanism of action.
PDFcategory: Treatment
Discussion covering all aspects of EM.
PDFcategory: General EM
Explanation of all aspects of chilblains (pernio), including symptoms, causes, and treatments.
PDFcategory: Pain and Other Related Topics
Intravenous lidocaine found to be effective in preventing and relieving chronic inflammatory and neuropathic pain.
PDFcategory: Pain and Other Related Topics
Mayo Clinic study finds corticosteroids most effective when EM is caused by surgery or trauma, when onset is rapid, and when patient is treated promptly.
PDFcategory: Treatment
Comprehensive review of literature on localized neuropathic pain and existing topical medications, identifying 5% lidocaine patch (Lidoderm/Versatis) and 8% capsaicin patch (Qutenza) as proven first-line treatments.
PDFcategory: Pain and Other Related Topics
Case report of a 42-year-old Japanese woman whose smartphone pictures helped doctors reach a diagnosis of EM.
PDFcategory: General EM
Case report of a 6-year-old girl treated with ibuprofen.
PDFcategory: Treatment
Study of 23 EM patients demonstrates dysfunction in peripheral nerve axons.
PDFcategory: Research
Case report of a 41-year-old female treated with a number of different drug therapies.
PDFcategory: Treatment
Mayo Clinic study finds corticosteroids most effective when EM is caused by surgery or trauma, when onset is rapid, and when patient is treated promptly.
PDFcategory: Treatment
Discussion of EM treatment options.
PDFcategory: Treatment
Case reports of three juveniles treated with a block of the lumbar sympathetic nerves.
PDFcategory: Treatment
Next-generation sequencing technology used at Mayo Clinic, Jacksonville, FL, to identify gain of function SCN9A mutation in a patient with symptoms of paroxysmal extreme pain disorder.
PDFcategory: Pain and Other Related Topics
Different mutations in the SCN9A gene are found to cause complete absence of pain or acute pain of EM.
PDFcategory: General EM
Pfizer study of five EM patients treated with sodium channel Nav1.7-blocker; drug was also tested on sensory neurons derived from patients’ stem cells.
PDFcategory: Research
Study demonstrates that drug therapy guided by genomic analysis and functional profiling can reduce neuropathic pain in patients with a sodium channel Nav1.7 mutation.
PDFcategory: Research
Explanation of the underlying molecular mechanism of sodium channels, in reference to article “Pharmacotherapy for pain in a family with inherited EM.”
PDFcategory: Research
Mayo Clinic study of 12 EM patients treated with topical midodrine cream.
PDFcategory: Treatment
Retrospective study explores possible association between temperature fluctuation during winter months and epidemic EM outbreaks in China, mainly occurring in adolescent females.
PDFcategory: General EM
Study establishes characteristics of one sodium channel Nav1.7 mutation.
PDFcategory: Research
The role of SCN9A gene mutations in three pain perception disorders, including EM.
PDFcategory: Research
Case report of a 31-year-old female treated with ziconotide administered intrathecally into the spinal canal.
PDFcategory: Treatment
Case report of a 45-year-old female with secondary EM treated with pregabalin and sertraline.
PDFcategory: Treatment
Case report of a 53-year-old male with facial EM demonstrates that EM can be mistaken for connective tissue disease.
PDFcategory: General EM
Study investigates the effects of mexiletine on one sodium channel Nav1.7 mutation.
PDFcategory: Research
Case report of a 31-year-old female treated with Botox.
PDFcategory: Treatment
Case report of a young girl whose EM is associated with the rare keratinizing disorder Olmsted syndrome.
PDFcategory: General EM
Case report of a 3-year-old boy treated with Zyrtec.
PDFcategory: Treatment
Recent advances in genetics have revealed that subtle changes in DNA could explain individual differences in pain sensitivity and perception.
PDFcategory: General EM
Case report of a 48-year-old female with secondary EM linked to essential thrombocythemia.
PDFcategory: General EM
Case report of a 58-year-old female treated with Botox.
PDFcategory: Treatment
Study finds small-fiber polyneuropathy prevalent in young patients with unexplained pain.
PDFcategory: Pain and Other Related Topics
Retrospective study of 36 EM patients treated with topical amitriptyline/ketamine cream.
PDFcategory: Treatment
Study identifies a new sodium channel Nav1.7 mutation that appears resistant to lidocaine and mexiletine.
PDFcategory: Research
New Zealand study finds that the incidence of EM may be greater than commonly accepted.
PDFcategory: General EM
Discussion of red ear syndrome, a possible variant of EM.
PDFcategory: General EM
Explanation of the autonomic nervous system and its effects on the timing of EM symptoms.
PDFcategory: General EM
Genetic and functional studies add to the evidence that sodium channel Nav1.7 is a major contributor to pain signaling in humans.
PDFcategory: Research
Case report of a 9-year-old boy treated with corticosteroids.
PDFcategory: Treatment
Case report of a 68-year-old female treated with corticosteroids and pregabalin.
PDFcategory: Treatment
Yale study finds that sodium channel Nav1.7 is responsible for the burning pain felt after burn injuries.
PDFcategory: Research
Mayo Clinic review of 41 EM patients and their quantitative sensory testing results.
PDFcategory: Research
Study identifies a new sodium channel Nav1.7 mutation in a 15-year-old girl with severe, progressive EM.
PDFcategory: Research
Summary of supplements used to treat EM.
PDFcategory: Treatment
Discussion of EM and a possible underlying cause.
PDFcategory: General EM
Study of 28 patients with unexplained small fiber neuropathy finds SCN9A gene mutations to be the cause.
PDFcategory: Research
Summary of EM treatment options.
PDFcategory: Treatment
Case report of a 64-year-old female with secondary EM triggered by aspirin withdrawal.
PDFcategory: General EM
Discussion of high-concentration 8% capsaicin patch (Qutenza) for treating neuropathic pain.
PDFcategory: Treatment
Case report of a 58-year-old male treated with mexiletine.
PDFcategory: Treatment
Case report of a 31-year-old female treated with massage therapy.
PDFcategory: Treatment
Study compares properties of different sodium channel Nav1.7 mutations that result in two separate pain conditions.
PDFcategory: Research
Researchers compare a patch-clamp robot with human patch-clamp in a functional assessment of a sodium channel Nav1.7 mutation linked to EM.
PDFcategory: Research
Explanation of the molecular mechanism of four sodium channel subunits and their role in neuropathic and inflammatory pain.
PDFcategory: Research
Study establishes characteristics of one sodium channel Nav1.7 mutation.
PDFcategory: Research
Study of a family with inherited EM suggests that variants in sodium channel Nav1.7 may influence susceptibility to pain.
PDFcategory: Research
Case reports of two juveniles treated with oral mexiletine.
PDFcategory: Treatment
Study compares gene mutations related to early- and late-onset inherited EM; late-onset EM is associated with less severe symptoms.
PDFcategory: Research
Study finds a newly identified sodium channel Nav1.7 mutation to be uniquely responsive to carbamazepine.
PDFcategory: Research
Study finds a newly identified sodium channel Nav1.7 mutation to be uniquely responsive to mexiletine.
PDFcategory: Research
Mayo Clinic study estimates the incidence of EM at 1.3 per 100,000 people per year.
PDFcategory: General EM
Retrospective study of eight EM patients admitted to Mayo Clinic’s pain rehabilitation program.
PDFcategory: Treatment
Study of patients with painful neuromas finds that increased expression of certain sodium channels, including Nav1.7, contributes to pain following nerve injury.
PDFcategory: Research
Case report of a 64-year-old female with secondary EM linked to thrombocytopenia.
PDFcategory: General EM
Study of 37 neuropathic pain patients finds that intravenous lidocaine may predict responsiveness to oral mexiletine.
PDFcategory: Pain and Other Related Topics
The role of sodium channel Nav1.7 mutations in three pain disorders, including EM.
PDFcategory: Research
Study links one sodium channel Nav1.7 mutation to reduced responsiveness to lidocaine.
PDFcategory: Research
Melatonin’s role in circadian rhythms and other biological functions; studies look for link between the hormone and scoliosis.
PDFcategory: Pain and Other Related Topics
Study identifies a sodium channel Nav1.7 mutation in a 15-year-old boy with inherited EM.
PDFcategory: Research
Case report of a 20-year-old male treated with corticosteroids and intravenous lidocaine infusion.
PDFcategory: Treatment
Study tests the effects of temperature on a sodium channel Nav1.7 mutation.
PDFcategory: Research
Different mutations of sodium channel Nav1.7 can trigger intense pain of EM or prevent all pain sensation.
PDFcategory: Research
Retrospective study of 32 EM patients finds small-fiber neuropathy and absence of sweating prevalent.
PDFcategory: Research
Case report of a 44-year-old male; general discussion of diagnostic testing, treatment options, and prognosis.
PDFcategory: General EM
Skin biopsies from 29 EM patients show a decrease in small nerve fiber density.
PDFcategory: Research
Case report of a 43-year-old female suggests that EM is a form of small-fiber neuropathy.
PDFcategory: General EM
A sodium channel Nav1.7 mutation renders sensory neurons hyperexcitable and sympathetic neurons hypoexcitable.
PDFcategory: Research
Discussion of EM treatments and lifestyle modifications.
PDFcategory: Treatment
Case report of a 17-year-old female treated with topical amitriptyline/ketamine gel.
PDFcategory: Treatment
Comparison of pregabalin and gabapentin for neuropathic pain relief.
PDFcategory: Treatment
Study identifies a new sodium channel Nav1.7 mutation in a family with inherited EM.
PDFcategory: Research
Study of 34 EM patients treated with lidocaine patch.
PDFcategory: Treatment
Study identifies a new sodium channel Nav1.7 mutation in a family with inherited EM.
PDFcategory: Research
Study tests a family with inherited EM for genetic linkage to chromosome 2q, as well as for variants in the SCN9A gene.
PDFcategory: Research
Study identifies multiple sodium channel Nav1.7 mutations in four families with inherited EM.
PDFcategory: Research
EM is the first human disorder in which it has been possible to associate an ion channel mutation with chronic neuropathic pain.
PDFcategory: Research
Case report of an 11-year-old boy treated with intravenous lidocaine infusion and oral mexiletine.
PDFcategory: Treatment
Case report of a 53-year-old male who remained resistant to all treatment.
PDFcategory: General EM
Case report of a 58-year-old female treated with venlafaxine.
PDFcategory: Treatment
Study of 21 EM patients treated with misoprostol.
PDFcategory: Treatment
Study identifies two sodium channel Nav1.7 mutations in a Chinese family.
PDFcategory: Research
Case report of a 42-year-old female with both Raynaud’s and EM, and discussion of the association between the two conditions.
PDFcategory: EM/Raynaud's
Mayo Clinic study of 67 EM patients finds most to have small-fiber neuropathy.
PDFcategory: Research
Case report of a 28-year-old female with inherited EM treated with cyclosporine.
PDFcategory: Treatment
Explanation of the autonomic and local mechanisms of skin blood flow and temperature regulation.
PDFcategory: General EM
Case report of a 37-year-old male with secondary EM triggered by ciclosporin.
PDFcategory: General EM
Case reports of two adults who developed EM symptoms after being treated for Raynaud’s with sertraline and fluoxetine.
PDFcategory: EM/Raynaud's
Study finds slower nerve conduction and hyperexcitable nerve fibers in EM patients.
PDFcategory: Research
Case report of five thrombocythemia patients with EM symptoms treated with aspirin.
PDFcategory: Treatment
Study of 12 EM patients treated with iloprost.
PDFcategory: Treatment
Summary of findings by Mørk and Kvernebo: the increased blood flow of EM may be caused by shunting of blood away from capillaries.
PDFcategory: Research
Study of 14 EM patients finds reduced skin capillary density.
PDFcategory: Research
Case reports of two juveniles treated with sodium nitroprusside infusion.
PDFcategory: Treatment
Study of 14 EM patients finds sympathetic nerve dysfunction associated with abnormal skin blood flow.
PDFcategory: Research
Study of ten EM patients treated with venlafaxine.
PDFcategory: Treatment
Case report of a 15-year-old girl treated with lidocaine patch.
PDFcategory: Treatment
Case report of a 28-year-old female with secondary EM treated with epidural bupivacaine.
PDFcategory: Treatment
Study of 53 Raynaud’s patients treated with fluoxetine or nifedipine.
PDFcategory: EM/Raynaud's
Case report of a 12-year-old boy treated with growth hormone.
PDFcategory: Treatment
Over-sensitization of small nerve fibers may be one possible cause of EM.
PDFcategory: General EM
Review of successful treatments, based on TEA’s member survey.
PDFcategory: Treatment
Study tests 14 EM patients for abnormal skin blood flow.
PDFcategory: Research
Study demonstrates connection between sleep onset, core body temperature, and vasodilation of the extremities.
PDFcategory: Pain and Other Related Topics
Review of 168 EM patients seen at Mayo Clinic from 1970 to 1994.
PDFcategory: General EM
Case report of a 4-year-old boy treated with bupivacaine/clonidine epidural.
PDFcategory: Treatment
Case report of a 25-year-old male treated with intravenous lidocaine infusion and oral mexiletine.
PDFcategory: Treatment
Study of 61 EM patients finds vasoconstriction prevalent.
PDFcategory: Research
Study shows that EM patients have diminished sympathetic vasoconstrictor responses.
PDFcategory: Research
Discussion covering all aspects of EM, in particular its connection to abnormal skin blood flow.
PDFcategory: General EM
Case reports of three adults treated with venlafaxine or sertraline.
PDFcategory: Treatment
Case report of a 15-year-old girl treated with sodium nitroprusside infusion.
PDFcategory: Treatment
Case reports of one child and one adult treated with gabapentin.
PDFcategory: Treatment
Study demonstrates that prolonged exposure to cold causes peripheral nerve damage.
PDFcategory: Pain and Other Related Topics
Case reports of two adolescent males treated with epidural analgesia.
PDFcategory: Treatment
Excerpt covering all aspects of EM and Raynaud’s, including cause, diagnosis, and treatments.
PDFcategory: EM/Raynaud's
Case report of a 68-year-old female treated with topical capsaicin cream.
PDFcategory: Treatment
Discussion of capsaicin for treating neuropathic pain.
PDFcategory: Treatment
Classification of three EM subtypes as separate disorders, and discussion of their causes.
PDFcategory: General EM
Case report of an Alabama family with inherited EM.
PDFcategory: General EM
Case report of an 18-year-old female treated with hypnotherapy.
PDFcategory: Treatment
Discussion covering all aspects of EM, including treatment for different subtypes.
PDFcategory: General EM
Case report of a 40-year-old female with both Raynaud’s and EM; subsequent discussion of the association between the two conditions.
PDFcategory: EM/Raynaud's
Report of EM epidemic associated with a viral respiratory infection.
PDFcategory: General EM
Discussion of EM symptoms and treatment with lumbar sympathetic nerve blocks.
PDFcategory: Treatment
Report of thrombocythemia patients presenting with EM symptoms.
PDFcategory: General EM
Case report of a female EM patient treated with biofeedback.
PDFcategory: Treatment